Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads

Keyphrases

• Phosphorylation 100%
• Abl Kinase 100%
• Kinase Activity 100%
• Kinase Inhibition 100%
• Agarose Beads 100%
• Whole Cell Extract 100%
• Recombinant 66%
• Cancer Cells 66%
• BCR-ABL 66%
• In Cancer 33%
• High-throughput Screening 33%
• Cell Signaling 33%
• Molecular Targeted Therapy 33%
• Drug Resistance 33%
• Multikinase Inhibitor 33%
• Glutathione 33%
• Targeted Drugs 33%
• C-Abl 33%
• Imatinib Mesylate 33%
• Clinical Laboratory 33%
• Drug Efficacy 33%
• Targeted Therapeutics 33%
• Kinase Assay 33%
• Cell-free Extract 33%
• Glutathione S-transferase 33%
• Tyrosine Kinase 33%
• Tyrosine Kinase Activity 33%
• Future Demand 33%
• High-throughput Assay 33%
• Assay Formats 33%
• Nonradioactive Assay 33%
• Clinical Diagnosis 33%
• Kinase Substrate 33%
• Increased Demand 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphotransferase 100%
• Agarose 100%
• Cell Extract 100%
• Abelson Kinase 100%
• Malignant Neoplasm 66%
• Glutathione 66%
• High-Throughput Screening 33%
• Recombinant 33%
• Protein Tyrosine Kinase 33%
• Phosphotransferase Inhibitor 33%
• Transferase 33%
• Imatinib 33%

Biochemistry, Genetics and Molecular Biology

• Agarose 100%
• Cell Extract 100%
• Phosphotransferase 100%
• Kinase 100%
• Whole Cell 100%
• Cancer Cell 28%
• Signal Transduction 14%
• Imatinib 14%
• Recombinant 14%
• Glutathione 14%
• High Throughput Screening 14%
• Drug Efficacy 14%
• Receptor Tyrosine Kinase 14%
• Glutathione S-Transferase 14%
• Drug Resistance 14%
• Mesylate 14%