TY - JOUR
T1 - Aspirin in childhood acute ischemic stroke
T2 - The evidence for treatment and efficacy testing
AU - Boucher, Alexander A.
AU - Taylor, J. Michael
AU - Luchtman-Jones, Lori
PY - 2019/6
Y1 - 2019/6
N2 - Aspirin is the most commonly prescribed antiplatelet agent worldwide, but evidence supporting its use varies by age and disease process. Despite its frequent use in childhood acute ischemic stroke prevention and management, major knowledge gaps exist about optimal pediatric aspirin use, particularly in this setting, where high-quality clinical trials are urgently needed. This review focuses upon the evidence for aspirin use in childhood acute ischemic stroke, includes a summary of aspirin pharmacology to highlight misconceptions and common clinical situations which may limit its efficacy, and discusses the techniques and potential role of laboratory monitoring of aspirin efficacy in children.
AB - Aspirin is the most commonly prescribed antiplatelet agent worldwide, but evidence supporting its use varies by age and disease process. Despite its frequent use in childhood acute ischemic stroke prevention and management, major knowledge gaps exist about optimal pediatric aspirin use, particularly in this setting, where high-quality clinical trials are urgently needed. This review focuses upon the evidence for aspirin use in childhood acute ischemic stroke, includes a summary of aspirin pharmacology to highlight misconceptions and common clinical situations which may limit its efficacy, and discusses the techniques and potential role of laboratory monitoring of aspirin efficacy in children.
KW - hemostasis and thrombosis
KW - non-malignant hematology
KW - pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85061615318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061615318&partnerID=8YFLogxK
U2 - 10.1002/pbc.27665
DO - 10.1002/pbc.27665
M3 - Review article
C2 - 30762284
AN - SCOPUS:85061615318
SN - 1545-5009
VL - 66
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 6
M1 - e27665
ER -