Aspirin and clopidogrel for prevention of ischemic stroke topical collection on stroke

Ruth M. Thomson, David C Anderson

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

This review examines the role of platelets in ischemic stroke, platelet activation mechanisms, aspirin's rise as an antithrombotic agent, clopidogrel's appearance on the stage, a possible role for combination therapy, antiplatelet resistance, practical considerations, and future directions. Reviewed in this chapter are issues central to optimal antiplatelet therapy: efficacy, safety, resistance, and biochemical/laboratory testing. Current guidelines do not recommend combination aspirin and clopidogrel use, however recent research indicates dual antiplatelet therapy with combined aspirin and clopidogrel may have specific roles in secondary prevention of ischemic stroke. A cautious and analytical interpretation of the literature is advised before application of this knowledge to clinical practice. The best recommendation at this time is to follow the published guidelines for secondary prevention of ischemic stroke.

Original languageEnglish (US)
Article number327
JournalCurrent neurology and neuroscience reports
Volume13
Issue number2
DOIs
StatePublished - Jan 9 2013

Keywords

  • Antiplatelet resistance
  • Aspirin
  • Aspirin resistance
  • CYP2C19 polymorphism
  • Clopidogrel
  • Clopidogrel resistance
  • Dipyridamole
  • Phosphodiasterase inhibitors
  • Stroke
  • Thienopyridines
  • Transient ischemic attack

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