With the development of reliable endoscopic closure techniques and tools, endoscopic full-thickness resection (EFTR) is emerging as a therapeutic option for the treatment of subepithelial tumors and epithelial neoplasia with significant fibrosis. EFTR may be categorized as “exposed” and “nonexposed.” In exposed EFTR, the full-thickness resection is undertaken with a tunneled or nontunneled technique, with subsequent closure of the defect. In nonexposed EFTR, a secure serosa-to-serosa apposition is achieved before full-thickness resection of the isolated lesion. This document reviews current techniques and devices used for EFTR and reviews clinical applications and outcomes.
Bibliographical noteFunding Information:
H. Aslanian: consultant for Olympus, Boston Scientific; speaker for GI Supply; M. Bhutani: advisory board for Medi-Globe (to Feb 2016); A. Goodman: consultant for Invendo Medical; D. Lichtenstein: consultant for Olympus; J. Melson: independent investigator, grant support from Boston Scientific; medical advisory board for Clinical Genomics; U. Navaneethan: consultant for Takeda, AbbVie, and Janssen; R. Pannala: consultant for Boston Scientific; research funding/support from Fujifilm and Apollo Endosurgery; M. Parsi: consultant for Boston Scientific; S. Sullivan: contracted research for Aspire Bariatrics, Allurion, Obalon, Elira, BARANova, USGI Medical, and GI Dynamics; consultant for Aspire Bariatrics, Obalon, Elira, USGI Medical, and GI Dynamics; stock warrants with Elira; N. Thosani: consultant for Boston Scientific, Medtronic, and Mederi; speaker for Boston Scientific and AbbVie; G. Trikudanathan: advisory Board for AbbVie; R. Watson: consultant for Apollo Endosurgery. All other authors disclosed no financial relationships relevant to this publication.
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