Ascaris suum: Immunization with soluble antigens in the guinea pig

B. E. Stromberg, E. J.L. Soulsby

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22 Scopus citations


The capacity of extracts or excretory-secretory products of adult and larval stages of Ascaris suum to induce protective immunity was evaluated. Extracts of 2nd, 3rd or 4th-stage larvae were unable to induce significant protection while adult worms did so. The excretory-secretory products of the adult or larval stages did not induce protection to a challenge infection. However, larvae cultured from the 3rd to the 4th stage produced a substance which was capable of inducing a significant level of protection. It is postulated that this immunogen is associated with the metabolism of the larvae and is involved with the developmental and moulting processes.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalInternational Journal for Parasitology
Issue number4
StatePublished - Aug 1977
Externally publishedYes

Bibliographical note

Funding Information:
Acknowiedgements-The authors wish to express their appreciationt o Mr. DerekM uncey,M rs. RosettaG oss and Miss Norma Molina for their assistancet hroughout these studies. This work was supported in part by U.S.P.H.S.R esearchG rant AI-06262R, esearcThr aining Grant AI-00302a nd BiomediaSl cienceSs upportG rant RRO-7083.


  • Ascaris suum
  • excretory-secretory products
  • guinea pig
  • immunization
  • soluble antigens


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