Arylamine N-acetyltransferase I

Rodney F. Minchin, Patrick E. Hanna, Jean Marie Dupret, Carston R Wagner, Fernando Rodrigues-Lima, Neville J. Butcher

Research output: Contribution to journalShort survey

58 Citations (Scopus)

Abstract

Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and shares homology to NAT genes found in most mammalian species. Gene expression occurs from at least two promoters and a number of tissue-specific transcripts have been identified. The gene is polymorphic with most mutations identified to date producing an unstable protein that is subject to polyubiquitination. The NAT1 protein contains a catalytic triad similar to a number of cysteine proteases and transglutaminases. NAT1 is widely distributed in the body, but the only endogenous substrate identified to date is the folate catabolite p-aminobenzoylglutamate. Recent links between NAT1 genotypes and susceptibility to spina bifida suggests that the enzyme has an important role in folate homeostasis.

Original languageEnglish (US)
Pages (from-to)1999-2005
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume39
Issue number11
DOIs
StatePublished - Sep 11 2007

Fingerprint

Arylamine N-Acetyltransferase
hydrazine
Genes
Folic Acid
Chromosomes, Human, Pair 8
Spinal Dysraphism
Transglutaminases
Cysteine Proteases
Substrates
Enzymes
Chromosomes
Gene expression
Proteins
Homeostasis
Genotype
Tissue
Gene Expression
Mutation

Keywords

  • Arylamine N-acetyltransferase
  • Catalytic triad
  • Folate metabolism
  • Polymorphism
  • Ubiquitination

Cite this

Minchin, R. F., Hanna, P. E., Dupret, J. M., Wagner, C. R., Rodrigues-Lima, F., & Butcher, N. J. (2007). Arylamine N-acetyltransferase I. International Journal of Biochemistry and Cell Biology, 39(11), 1999-2005. https://doi.org/10.1016/j.biocel.2006.12.006

Arylamine N-acetyltransferase I. / Minchin, Rodney F.; Hanna, Patrick E.; Dupret, Jean Marie; Wagner, Carston R; Rodrigues-Lima, Fernando; Butcher, Neville J.

In: International Journal of Biochemistry and Cell Biology, Vol. 39, No. 11, 11.09.2007, p. 1999-2005.

Research output: Contribution to journalShort survey

Minchin, RF, Hanna, PE, Dupret, JM, Wagner, CR, Rodrigues-Lima, F & Butcher, NJ 2007, 'Arylamine N-acetyltransferase I', International Journal of Biochemistry and Cell Biology, vol. 39, no. 11, pp. 1999-2005. https://doi.org/10.1016/j.biocel.2006.12.006
Minchin RF, Hanna PE, Dupret JM, Wagner CR, Rodrigues-Lima F, Butcher NJ. Arylamine N-acetyltransferase I. International Journal of Biochemistry and Cell Biology. 2007 Sep 11;39(11):1999-2005. https://doi.org/10.1016/j.biocel.2006.12.006
Minchin, Rodney F. ; Hanna, Patrick E. ; Dupret, Jean Marie ; Wagner, Carston R ; Rodrigues-Lima, Fernando ; Butcher, Neville J. / Arylamine N-acetyltransferase I. In: International Journal of Biochemistry and Cell Biology. 2007 ; Vol. 39, No. 11. pp. 1999-2005.
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