Artifactual Elevation of Serum Creatinine Level due to Fasting

Stephen R. Mascioli, John P. Bantle, Esther F. Freier, Byron J. Hoogwerf

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Abnormal serum creatinine (1.6 mg/dL) and creatinine clearance (33 mL/min) levels found in a 50-year-old woman during fasting were corrected with refeeding. Five healthy subjects who fasted for 96 hours demonstrated an increase in their mean serum creatinine level from 1.0±0.08 to 1.7±0.11 mg/dL as determined by Jaffé’s method. This increase was probably an artifact caused by the rise in the serum acetoacetate level during fasting. The serum creatinine level determined by an enzymatic method and serum urea nitrogen level did not change substantially during the fast. We conclude that fasting may cause an artifactual increase in the serum creatinine level determined by Jaffé’s method, the method used by most clinical laboratories.

Original languageEnglish (US)
Pages (from-to)1575-1576
Number of pages2
JournalArchives of Internal Medicine
Issue number8
StatePublished - Aug 1984


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