Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

Grace Lai, Karra Muller, Bob Carter, Clark Chen

Research output: Contribution to journalArticle

Abstract

Background: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. Case Description: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. Conclusion: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.

Original languageEnglish (US)
Pages (from-to)S295-S299
JournalSurgical Neurology International
Volume6
DOIs
StatePublished - Sep 1 2015

Keywords

  • Arteriovenous malformation
  • isocitrate dehydrogenase 1
  • oligodendroglioma

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