TY - JOUR
T1 - Arterial stiffness and decline in kidney function
AU - Sedaghat, Sanaz
AU - Mattace-Raso, Francesco U.S.
AU - Hoorn, Ewout J.
AU - Uitterlinden, Andre G.
AU - Hofman, Albert
AU - Ikram, M. Arfan
AU - Franco, Oscar H.
AU - Dehghan, Abbas
N1 - Publisher Copyright:
© 2015 by the American Society of Nephrology.
PY - 2015/12/7
Y1 - 2015/12/7
N2 - Background and objectives The independent link between arterial stiffness and CKD remains unknown. We investigated the association of indicators of arterial stiffness with decline in kidney function. Design, setting, participants, & measurements We studied 3666 participants (mean age =65 years old; 58% women) from the Rotterdam Study. Pulse pressure (PP), carotid stiffness, and pulse wave velocity (PWV) were measured.We created genetic risk scores for PP and PWV. Annual declines in kidney function and incident CKD were assessed using eGFR. To put our findings in context of the literature, we performed a meta-analysis of the available population–based studies. Results After a median (interquartile range) follow–up time of 11 (10.7–11.3) years, 601 participantswith incident CKD were recognized. In the model adjusted for age, sex, mean arterial pressure, heart rate, and baseline GFR, each SD higher PP was associated with 0.15-ml/min per 1.73 m2 steeper annual eGFR decline (95% confidence interval [95% CI], 0.10 to 0.20) and 11%higher risk of incident CKD(95% CI, 1.05 to 1.18). Each SD greater carotid stiffnesswas associatedwith 0.08-ml/min per 1.73m2 steeper annual eGFR decline (95%CI, 0.04 to 0.13) and 13% higher risk of incident CKD (95% CI, 1.05 to 1.22). Each SD higher PWV was associated with 7% higher risk of incident CKD (95% CI, 1.00 to 1.14). Incorporating our findings in a meta-analysis, each SD higher PP and PWV were associated with 16% (95% CI, 1.12 to 1.21) and 8% (95% CI, 1.03 to 1.14) higher risks of incident CKD. Each SD higher PP genetic risk score was associated with 0.06-ml/min per 1.73 m2 steeper annual eGFR decline (95% CI, 0.01 to 0.10) and 8%higher risk of incident CKD(95% CI, 1.03 to 1.14). Therewas no association between PWV genetic risk score and kidney function decline. Conclusions Higher indices of arterial stiffness are associated with steeper decline in kidney function. This suggests that vascular stiffness could be considered as a target for delaying decline in kidney function.
AB - Background and objectives The independent link between arterial stiffness and CKD remains unknown. We investigated the association of indicators of arterial stiffness with decline in kidney function. Design, setting, participants, & measurements We studied 3666 participants (mean age =65 years old; 58% women) from the Rotterdam Study. Pulse pressure (PP), carotid stiffness, and pulse wave velocity (PWV) were measured.We created genetic risk scores for PP and PWV. Annual declines in kidney function and incident CKD were assessed using eGFR. To put our findings in context of the literature, we performed a meta-analysis of the available population–based studies. Results After a median (interquartile range) follow–up time of 11 (10.7–11.3) years, 601 participantswith incident CKD were recognized. In the model adjusted for age, sex, mean arterial pressure, heart rate, and baseline GFR, each SD higher PP was associated with 0.15-ml/min per 1.73 m2 steeper annual eGFR decline (95% confidence interval [95% CI], 0.10 to 0.20) and 11%higher risk of incident CKD(95% CI, 1.05 to 1.18). Each SD greater carotid stiffnesswas associatedwith 0.08-ml/min per 1.73m2 steeper annual eGFR decline (95%CI, 0.04 to 0.13) and 13% higher risk of incident CKD (95% CI, 1.05 to 1.22). Each SD higher PWV was associated with 7% higher risk of incident CKD (95% CI, 1.00 to 1.14). Incorporating our findings in a meta-analysis, each SD higher PP and PWV were associated with 16% (95% CI, 1.12 to 1.21) and 8% (95% CI, 1.03 to 1.14) higher risks of incident CKD. Each SD higher PP genetic risk score was associated with 0.06-ml/min per 1.73 m2 steeper annual eGFR decline (95% CI, 0.01 to 0.10) and 8%higher risk of incident CKD(95% CI, 1.03 to 1.14). Therewas no association between PWV genetic risk score and kidney function decline. Conclusions Higher indices of arterial stiffness are associated with steeper decline in kidney function. This suggests that vascular stiffness could be considered as a target for delaying decline in kidney function.
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U2 - 10.2215/CJN.03000315
DO - 10.2215/CJN.03000315
M3 - Article
C2 - 26563380
AN - SCOPUS:84957804523
SN - 1555-9041
VL - 10
SP - 2190
EP - 2197
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 12
ER -
