TY - JOUR
T1 - Arterial remodeling influences the development of intimal hyperplasia after stent implantation
AU - Endo, Akihiro
AU - Hirayama, Haruo
AU - Yoshida, Osamu
AU - Arakawa, Tomoharu
AU - Akima, Takashi
AU - Yamada, Takumi
AU - Nanasato, Mamoru
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - OBJECTIVES: We examined whether preinterventional arterial remodeling influenced the interventional results after stenting. BACKGROUND: Arterial remodeling is seen in atherosclerotic lesions, and it may play an important role in the early stage of atherosclerosis. METHODS: We examined 113 lesions that underwent elective stenting using tubular slotted stents under intravascular ultrasound guidance. The lesions were divided into three groups - adequate, intermediate and inadequate remodeling group - according to preinterventional arterial remodeling. The patients were subjected to coronary angiography and intravascular ultrasound evaluation on average 6.4 months after stenting. RESULTS: At baseline and immediately after stenting, there were no differences in quantitative angiographic analysis among remodeling groups. However, the plaque cross-sectional area (CSA) in the minimal lumen CSA at preintervention and intimal hyperplasia CSA at follow-up were significantly larger in the adequate remodeling group than in the inadequate remodeling group. The restenosis rate of stenting for the lesions with inadequate arterial remodeling was very low (9.4%). A significant positive correlation was found between preinterventional plaque CSA and intimal hyperplasia CSA at follow-up (r = 0.47, p < 0.0001). Moreover, remodeling index significantly correlated with relative intimal hyperplasia CSA (r = 0.28, p < 0.01). CONCLUSIONS: Preinterventional arterial remodeling influenced the development of intimal hyperplasia after stenting.
AB - OBJECTIVES: We examined whether preinterventional arterial remodeling influenced the interventional results after stenting. BACKGROUND: Arterial remodeling is seen in atherosclerotic lesions, and it may play an important role in the early stage of atherosclerosis. METHODS: We examined 113 lesions that underwent elective stenting using tubular slotted stents under intravascular ultrasound guidance. The lesions were divided into three groups - adequate, intermediate and inadequate remodeling group - according to preinterventional arterial remodeling. The patients were subjected to coronary angiography and intravascular ultrasound evaluation on average 6.4 months after stenting. RESULTS: At baseline and immediately after stenting, there were no differences in quantitative angiographic analysis among remodeling groups. However, the plaque cross-sectional area (CSA) in the minimal lumen CSA at preintervention and intimal hyperplasia CSA at follow-up were significantly larger in the adequate remodeling group than in the inadequate remodeling group. The restenosis rate of stenting for the lesions with inadequate arterial remodeling was very low (9.4%). A significant positive correlation was found between preinterventional plaque CSA and intimal hyperplasia CSA at follow-up (r = 0.47, p < 0.0001). Moreover, remodeling index significantly correlated with relative intimal hyperplasia CSA (r = 0.28, p < 0.01). CONCLUSIONS: Preinterventional arterial remodeling influenced the development of intimal hyperplasia after stenting.
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U2 - 10.1016/S0735-1097(00)01038-X
DO - 10.1016/S0735-1097(00)01038-X
M3 - Article
C2 - 11153775
AN - SCOPUS:0035162499
VL - 37
SP - 70
EP - 75
JO - Journal of the American College of Cardiology.
JF - Journal of the American College of Cardiology.
SN - 0735-1097
IS - 1
ER -