Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus

Abdel Rahim Ibrahim, Y. J. Abul-Hajj

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24 Scopus citations


The conversion of 5-hydroxyflavone by various microorganisms was studied. Among them, Streptomyces fulvissimus was the sole microbe which produced a new polar metabolite from 5-hydroxyflavone in addition to 5,4'-dihydroxy- and 5,3',4'-trihydroxyflavone. The structure of this polar metabolite was determined to be 5,4'-dihydroxyflavone-4'-sulfate on the basis of mass, infrared, and nuclear magnetic resonance spectroscopies. These results demonstrate that S. fulvissimus catalyzes sulfation at the 4' position of 5,4'-dihydroxyflavone.

Original languageEnglish (US)
Pages (from-to)3140-3142
Number of pages3
JournalApplied and environmental microbiology
Issue number12
StatePublished - Jan 1 1989
Externally publishedYes


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