Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Carston R. Wagner; Edward J. McIntee; Raymond F. Schinazi; Timothy W. Abraham

doi:10.1016/0960-894X(95)00302-A

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Carston R. Wagner
, Edward J. McIntee
, Raymond F. Schinazi
, Timothy W. Abraham

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

Original language	English (US)
Pages (from-to)	1819-1824
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(95)00302-A
State	Published - Aug 17 1995

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Copyright 2015 Elsevier B.V., All rights reserved.

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abstract = "A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.",

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AU - Wagner, Carston R.

AU - McIntee, Edward J.

AU - Schinazi, Raymond F.

AU - Abraham, Timothy W.

PY - 1995/8/17

Y1 - 1995/8/17

N2 - A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

AB - A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

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UR - https://www.scopus.com/pages/publications/0029118114#tab=citedBy

U2 - 10.1016/0960-894X(95)00302-A

DO - 10.1016/0960-894X(95)00302-A

M3 - Article

AN - SCOPUS:0029118114

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IS - 16

ER -

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Abstract

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