Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Carston R. Wagner; Edward J. McIntee; Raymond F. Schinazi; Timothy W. Abraham

doi:10.1016/0960-894X(95)00302-A

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Carston R. Wagner, Edward J. McIntee, Raymond F. Schinazi, Timothy W. Abraham

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

Original language	English (US)
Pages (from-to)	1819-1824
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(95)00302-A
State	Published - Aug 17 1995

Bibliographical note

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/0960-894X(95)00302-A

Find It

Find It at U of M Libraries

Cite this

@article{ce4b2da4040d4ed7963d6e662458d858,

title = "Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication",

abstract = "A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.",

author = "Wagner, {Carston R.} and McIntee, {Edward J.} and Schinazi, {Raymond F.} and Abraham, {Timothy W.}",

year = "1995",

month = aug,

day = "17",

doi = "10.1016/0960-894X(95)00302-A",

language = "English (US)",

volume = "5",

pages = "1819--1824",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "16",

}

TY - JOUR

T1 - Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

AU - Wagner, Carston R.

AU - McIntee, Edward J.

AU - Schinazi, Raymond F.

AU - Abraham, Timothy W.

PY - 1995/8/17

Y1 - 1995/8/17

N2 - A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

AB - A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

UR - http://www.scopus.com/inward/record.url?scp=0029118114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029118114&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(95)00302-A

DO - 10.1016/0960-894X(95)00302-A

M3 - Article

AN - SCOPUS:0029118114

SN - 0960-894X

VL - 5

SP - 1819

EP - 1824

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Abstract

Bibliographical note

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this