Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Carston R. Wagner, Edward J. McIntee, Raymond F. Schinazi, Timothy W. Abraham

Research output: Contribution to journalArticle

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Abstract

A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

Original languageEnglish (US)
Pages (from-to)1819-1824
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number16
DOIs
StatePublished - Aug 17 1995

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