ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group

Amy M. Linabery; Crystal N. Blommer; Logan G. Spector; Stella M. Davies; Leslie L. Robison; Julie A. Ross

doi:10.1016/j.leukres.2013.04.022

ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group

Amy M. Linabery
, Crystal N. Blommer
, Logan G. Spector
, Stella M. Davies
, Leslie L. Robison
, Julie A. Ross

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Case-control comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >1.33, P_trend≤0.001). No heterogeneity was observed between ORs for males and females (all P_interaction>0.48). Likewise, no significant genotype-birth weight interactions were detected (all P_interaction>0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.

Original language	English (US)
Pages (from-to)	936-942
Number of pages	7
Journal	Leukemia research
Volume	37
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2013.04.022
State	Published - Aug 2013

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health [grant numbers K05 CA157439, U10CA13539, U10CA98543, T32 CA099936]; and the Children's Cancer Research Fund, Minneapolis, MN.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute lymphoblastic leukemia
Children
Gene-environment interaction
Genetic susceptibility

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10.1016/j.leukres.2013.04.022

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title = "ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group",

abstract = "Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Case-control comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >1.33, Ptrend≤0.001). No heterogeneity was observed between ORs for males and females (all Pinteraction>0.48). Likewise, no significant genotype-birth weight interactions were detected (all Pinteraction>0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.",

keywords = "Acute lymphoblastic leukemia, Children, Gene-environment interaction, Genetic susceptibility",

author = "Linabery, \{Amy M.\} and Blommer, \{Crystal N.\} and Spector, \{Logan G.\} and Davies, \{Stella M.\} and Robison, \{Leslie L.\} and Ross, \{Julie A.\}",

note = "Funding Information: This work was supported by the National Institutes of Health [grant numbers K05 CA157439, U10CA13539, U10CA98543, T32 CA099936]; and the Children's Cancer Research Fund, Minneapolis, MN. ",

year = "2013",

month = aug,

doi = "10.1016/j.leukres.2013.04.022",

language = "English (US)",

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AU - Blommer, Crystal N.

AU - Spector, Logan G.

AU - Davies, Stella M.

AU - Robison, Leslie L.

AU - Ross, Julie A.

N1 - Funding Information: This work was supported by the National Institutes of Health [grant numbers K05 CA157439, U10CA13539, U10CA98543, T32 CA099936]; and the Children's Cancer Research Fund, Minneapolis, MN.

PY - 2013/8

Y1 - 2013/8

N2 - Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Case-control comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >1.33, Ptrend≤0.001). No heterogeneity was observed between ORs for males and females (all Pinteraction>0.48). Likewise, no significant genotype-birth weight interactions were detected (all Pinteraction>0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.

AB - Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Case-control comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >1.33, Ptrend≤0.001). No heterogeneity was observed between ORs for males and females (all Pinteraction>0.48). Likewise, no significant genotype-birth weight interactions were detected (all Pinteraction>0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.

KW - Acute lymphoblastic leukemia

KW - Children

KW - Gene-environment interaction

KW - Genetic susceptibility

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SN - 0145-2126

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JO - Leukemia research

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ER -

ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group

Abstract

Bibliographical note

UN SDGs

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