Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Case-control comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >1.33, Ptrend≤0.001). No heterogeneity was observed between ORs for males and females (all Pinteraction>0.48). Likewise, no significant genotype-birth weight interactions were detected (all Pinteraction>0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health [grant numbers K05 CA157439, U10CA13539, U10CA98543, T32 CA099936]; and the Children's Cancer Research Fund, Minneapolis, MN.
- Acute lymphoblastic leukemia
- Gene-environment interaction
- Genetic susceptibility