Abstract
It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 377-378 |
| Number of pages | 2 |
| Journal | Neuron |
| Volume | 70 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 12 2011 |