Are Polyglutamine Diseases Expanding?

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.

Original languageEnglish (US)
Pages (from-to)377-378
Number of pages2
JournalNeuron
Volume70
Issue number3
DOIs
StatePublished - May 12 2011

Fingerprint

Antisense RNA
Peptides
Disease Progression
Neurons
polyglutamine
Huntington Disease-Like 2

Cite this

Are Polyglutamine Diseases Expanding? / Orr, Harry T.

In: Neuron, Vol. 70, No. 3, 12.05.2011, p. 377-378.

Research output: Contribution to journalShort survey

Orr, Harry T. / Are Polyglutamine Diseases Expanding?. In: Neuron. 2011 ; Vol. 70, No. 3. pp. 377-378.
@article{95f11cee94694fe685fadb452a4f9f27,
title = "Are Polyglutamine Diseases Expanding?",
abstract = "It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.",
author = "Orr, {Harry T}",
year = "2011",
month = "5",
day = "12",
doi = "10.1016/j.neuron.2011.04.015",
language = "English (US)",
volume = "70",
pages = "377--378",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Are Polyglutamine Diseases Expanding?

AU - Orr, Harry T

PY - 2011/5/12

Y1 - 2011/5/12

N2 - It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.

AB - It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.

UR - http://www.scopus.com/inward/record.url?scp=79955655048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955655048&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2011.04.015

DO - 10.1016/j.neuron.2011.04.015

M3 - Short survey

VL - 70

SP - 377

EP - 378

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -