Are Polyglutamine Diseases Expanding?

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.

Original languageEnglish (US)
Pages (from-to)377-378
Number of pages2
Issue number3
StatePublished - May 12 2011

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