Are environmental levels of bisphenol A associated with reproductive function in fertile men?

Jaime Mendiola, Niels Jørgensen, Anna Maria Andersson, Antonia M. Calafat, Xiaoyun Ye, J. Bruce Redmon, Erma Z. Drobnis, Christina Wang, Amy Sparks, Sally W. Thurston, Fan Liu, Shanna H. Swan

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.

Original languageEnglish (US)
Pages (from-to)1286-1291
Number of pages6
JournalEnvironmental health perspectives
Volume118
Issue number9
DOIs
StatePublished - Sep 1 2010

Fingerprint

Androgens
Sex Hormone-Binding Globulin
Semen Analysis
Luteinizing Hormone
Semen
Testosterone
Urine
Hormones
Social Adjustment
bisphenol A
Follicle Stimulating Hormone
Pregnant Women
Estradiol
Rodentia
Linear Models
Creatinine
Body Mass Index
Smoking
Regression Analysis
Serum

Keywords

  • Bisphenol A
  • Endocrine disruptors
  • Male hormones
  • Semen quality
  • Xenoestrogens

Cite this

Mendiola, J., Jørgensen, N., Andersson, A. M., Calafat, A. M., Ye, X., Redmon, J. B., ... Swan, S. H. (2010). Are environmental levels of bisphenol A associated with reproductive function in fertile men? Environmental health perspectives, 118(9), 1286-1291. https://doi.org/10.1289/ehp.1002037

Are environmental levels of bisphenol A associated with reproductive function in fertile men? / Mendiola, Jaime; Jørgensen, Niels; Andersson, Anna Maria; Calafat, Antonia M.; Ye, Xiaoyun; Redmon, J. Bruce; Drobnis, Erma Z.; Wang, Christina; Sparks, Amy; Thurston, Sally W.; Liu, Fan; Swan, Shanna H.

In: Environmental health perspectives, Vol. 118, No. 9, 01.09.2010, p. 1286-1291.

Research output: Contribution to journalArticle

Mendiola, J, Jørgensen, N, Andersson, AM, Calafat, AM, Ye, X, Redmon, JB, Drobnis, EZ, Wang, C, Sparks, A, Thurston, SW, Liu, F & Swan, SH 2010, 'Are environmental levels of bisphenol A associated with reproductive function in fertile men?', Environmental health perspectives, vol. 118, no. 9, pp. 1286-1291. https://doi.org/10.1289/ehp.1002037
Mendiola, Jaime ; Jørgensen, Niels ; Andersson, Anna Maria ; Calafat, Antonia M. ; Ye, Xiaoyun ; Redmon, J. Bruce ; Drobnis, Erma Z. ; Wang, Christina ; Sparks, Amy ; Thurston, Sally W. ; Liu, Fan ; Swan, Shanna H. / Are environmental levels of bisphenol A associated with reproductive function in fertile men?. In: Environmental health perspectives. 2010 ; Vol. 118, No. 9. pp. 1286-1291.
@article{0a7291280f9640a7ac6ca5d6f513324c,
title = "Are environmental levels of bisphenol A associated with reproductive function in fertile men?",
abstract = "Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.",
keywords = "Bisphenol A, Endocrine disruptors, Male hormones, Semen quality, Xenoestrogens",
author = "Jaime Mendiola and Niels J{\o}rgensen and Andersson, {Anna Maria} and Calafat, {Antonia M.} and Xiaoyun Ye and Redmon, {J. Bruce} and Drobnis, {Erma Z.} and Christina Wang and Amy Sparks and Thurston, {Sally W.} and Fan Liu and Swan, {Shanna H.}",
year = "2010",
month = "9",
day = "1",
doi = "10.1289/ehp.1002037",
language = "English (US)",
volume = "118",
pages = "1286--1291",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "9",

}

TY - JOUR

T1 - Are environmental levels of bisphenol A associated with reproductive function in fertile men?

AU - Mendiola, Jaime

AU - Jørgensen, Niels

AU - Andersson, Anna Maria

AU - Calafat, Antonia M.

AU - Ye, Xiaoyun

AU - Redmon, J. Bruce

AU - Drobnis, Erma Z.

AU - Wang, Christina

AU - Sparks, Amy

AU - Thurston, Sally W.

AU - Liu, Fan

AU - Swan, Shanna H.

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.

AB - Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.

KW - Bisphenol A

KW - Endocrine disruptors

KW - Male hormones

KW - Semen quality

KW - Xenoestrogens

UR - http://www.scopus.com/inward/record.url?scp=77956791365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956791365&partnerID=8YFLogxK

U2 - 10.1289/ehp.1002037

DO - 10.1289/ehp.1002037

M3 - Article

VL - 118

SP - 1286

EP - 1291

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 9

ER -