Abstract
Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1286-1291 |
| Number of pages | 6 |
| Journal | Environmental health perspectives |
| Volume | 118 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2010 |
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Keywords
- Bisphenol A
- Endocrine disruptors
- Male hormones
- Semen quality
- Xenoestrogens
Cite this
Are environmental levels of bisphenol A associated with reproductive function in fertile men? / Mendiola, Jaime; Jørgensen, Niels; Andersson, Anna Maria; Calafat, Antonia M.; Ye, Xiaoyun; Redmon, J. Bruce; Drobnis, Erma Z.; Wang, Christina; Sparks, Amy; Thurston, Sally W.; Liu, Fan; Swan, Shanna H.
In: Environmental health perspectives, Vol. 118, No. 9, 01.09.2010, p. 1286-1291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Are environmental levels of bisphenol A associated with reproductive function in fertile men?
AU - Mendiola, Jaime
AU - Jørgensen, Niels
AU - Andersson, Anna Maria
AU - Calafat, Antonia M.
AU - Ye, Xiaoyun
AU - Redmon, J. Bruce
AU - Drobnis, Erma Z.
AU - Wang, Christina
AU - Sparks, Amy
AU - Thurston, Sally W.
AU - Liu, Fan
AU - Swan, Shanna H.
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.
AB - Background: Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives: We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods: Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone-binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results: After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions: Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.
KW - Bisphenol A
KW - Endocrine disruptors
KW - Male hormones
KW - Semen quality
KW - Xenoestrogens
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UR - http://www.scopus.com/inward/citedby.url?scp=77956791365&partnerID=8YFLogxK
U2 - 10.1289/ehp.1002037
DO - 10.1289/ehp.1002037
M3 - Article
VL - 118
SP - 1286
EP - 1291
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 9
ER -