TY - JOUR
T1 - Aqueous chlorination and ozonation studies I. Structure-toxicity correlations of phenolic compounds to Daphnia magna
AU - Kopperman, Herbert L.
AU - Carlson, Robert M
AU - Caple, Ronald
PY - 1974/10
Y1 - 1974/10
N2 - A correlation showing the dependency of the observed biological activity (LC50) of a series of phenols to the free energy related terms, π, F and R (field and resonance), which are specific for each compound, has been observed for the freshwater invertebrate, Daphnia magna. A series of 14 phenols was investigated and with F and R considered to be additive terms the following correlation was obtained. Log 1/c = 0.500 π + 0.453 F + 0.636 R + 3.731 r = 0.978 In those phenols containing chlorine it was noted the toxicity increased with increased chlorine content.
AB - A correlation showing the dependency of the observed biological activity (LC50) of a series of phenols to the free energy related terms, π, F and R (field and resonance), which are specific for each compound, has been observed for the freshwater invertebrate, Daphnia magna. A series of 14 phenols was investigated and with F and R considered to be additive terms the following correlation was obtained. Log 1/c = 0.500 π + 0.453 F + 0.636 R + 3.731 r = 0.978 In those phenols containing chlorine it was noted the toxicity increased with increased chlorine content.
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U2 - 10.1016/0009-2797(74)90015-5
DO - 10.1016/0009-2797(74)90015-5
M3 - Article
C2 - 4430014
AN - SCOPUS:0016283363
SN - 0009-2797
VL - 9
SP - 245
EP - 251
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 4
ER -