Approaches to the synthesis of immunolides: Selective immunomodulatory macrolides for cystic fibrosis

Robert A. Fecik, Phuongdiep L. Nguyen, Lakshmanan Venkatraman

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

The discovery of the clinical effectiveness of erythromycin and azithromycin in inflammatory airway diseases has inspired the discovery and development of macrolides with selective immunomodulatory activity. Erythromycin degradation continues to be a source of novel macrolides with a variety of selective biological activities. New technologies for drug discovery based in the emerging field of combinatorial biosynthesis provide the medicinal chemist with novel approaches toward the discovery of novel macrolides. Recent efforts to integrate synthetic organic medicinal chemistry with combinatorial biosynthesis have expanded the number of techniques available for macrolide synthesis.

Original languageEnglish (US)
Pages (from-to)741-747
Number of pages7
JournalCurrent Opinion in Drug Discovery and Development
Volume8
Issue number6
StatePublished - Nov 1 2005

Keywords

  • Antibacterials
  • Cystic fibrosis
  • Erythromycin
  • Macrolides
  • Synthesis

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