Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families

Malcolm N Blumenthal, S. S. Rich, R. King, J. Weber

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Evidence for linkage of asthma and its associated phenotypes with susceptibility genes on chromosome 12 has been demonstrated in one group of Minnesota families. The evidence is strong in affected sib pairs and weakens in analysis of the large pedigrees. A second group of families provided little evidence for such linkage. A discrepancy has been demonstrated in different families. This may be due to several factors, including genetic heterogeneity and gene-gene, or gene-environmental interaction effects as well as the statistical power of the sample population used.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalClinical and Experimental Allergy, Supplement
Volume28
Issue number1
StatePublished - Apr 1998

Fingerprint Dive into the research topics of 'Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families'. Together they form a unique fingerprint.

Cite this