Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.

Original languageEnglish (US)
Pages (from-to)1001-1008
Number of pages8
JournalChemical research in toxicology
Volume23
Issue number6
DOIs
StatePublished - Jun 21 2010

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