Applications of quorum sensing in biotechnology

Swati Choudhary, Claudia Schmidt-Dannert

Research output: Contribution to journalShort surveypeer-review

140 Scopus citations


Many unicellular microorganisms use small signaling molecules to determine their local concentration. The processes involved in the production and recognition of these signals are collectively known as quorum sensing (QS). This form of cell-cell communication is used by unicellular microorganisms to co-ordinate their activities, which allows them to function as multi-cellular systems. Recently, several groups have demonstrated artificial intra-species and inter-species communication through synthetic circuits which incorporate components of bacterial QS systems. Engineered QS-based circuits have a wide range of applications such as production of biochemicals, tissue engineering, and mixed-species fermentations. They are also highly useful in designing microbial biosensors to identify bacterial species present in the environment and within living organisms. In this review, we first provide an overview of bacterial QS systems and the mechanisms developed by bacteria and higher organisms to obstruct QS communications. Next, we describe the different ways in which researchers have designed QS-based circuits and their applications in biotechnology. Finally, disruption of quorum sensing is discussed as a viable strategy for preventing the formation of harmful biofilms in membrane bioreactors and marine transportation.

Original languageEnglish (US)
Pages (from-to)1267-1279
Number of pages13
JournalApplied Microbiology and Biotechnology
Issue number5
StatePublished - May 2010


  • Biofilm
  • Biotechnology
  • Quorum sensing
  • Synthetic biology


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