Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in positron emission tomography

Mekhman S. Yusubov, Dmitrii Yu Svitich, Mariia S. Larkina, Viktor V. Zhdankin

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

This review summarizes the applications of iodonium compounds in the rapidly developing field of Positron Emission Tomography (PET). Reactions of diaryliodonium salts with fluoride anion have found wide practical application in PET as a fast and convenient method for the introduction of the radioactive [18F]-fluoride into radiotracer molecules. The best synthetic methods for the preparation of iodonium precursors for PET are described, the mechanistic aspects of nucleophilic fluorination reaction are discussed, and specific examples of the preparation of PET radioligands are provided.

Original languageEnglish (US)
Pages (from-to)364-395
Number of pages32
JournalArkivoc
Volume2013
Issue number1
DOIs
StatePublished - Jul 20 2013

Keywords

  • Fluorine-18
  • Iodonium salts
  • Iodonium ylides
  • Nucleophilic fluorination
  • Pet

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