Application of transport phenomena analysis technique to cerebrospinal fluid

Cornelius H Lam, E. A. Hansen, W. A. Hall, Allison Hubel

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The study of hydrocephalus and the modeling of cerebrospinal fluid flow have proceeded in the past using mathematical analysis that was very capable of prediction phenomenonologically but not well in physiologic parameters. In this paper, the basis of fluid dynamics at the physiologic state is explained using first established equations of transport phenomenon. Then, microscopic and molecular level techniques of modeling are described using porous media theory and chemical kinetic theory and then applied to cerebrospinal fluid (CSF) dynamics. Using techniques of transport analysis allows the field of cerebrospinal fluid dynamics to approach the level of sophistication of urine and blood transport. Concepts such as intracellular and intercellular pathways, compartmentalization, and tortuosity are associated with quantifiable parameters that are relevant to the anatomy and physiology of cerebrospinal fluid transport. The engineering field of transport phenomenon is rich and steeped in architectural, aeronautical, nautical, and more recently biological history. This paper summarizes and reviews the approaches that have been taken in the field of engineering and applies it to CSF flow.

Original languageEnglish (US)
Pages (from-to)317-326
Number of pages10
JournalJournal of Neurosurgical Sciences
Volume57
Issue number4
StatePublished - Dec 1 2013

Fingerprint

Cerebrospinal Fluid
Hydrodynamics
Hydrocephalus
Anatomy
History
Urine

Keywords

  • Biomedical engineering
  • Cerebrospinal fluid
  • Hydrocephalus

Cite this

Application of transport phenomena analysis technique to cerebrospinal fluid. / Lam, Cornelius H; Hansen, E. A.; Hall, W. A.; Hubel, Allison.

In: Journal of Neurosurgical Sciences, Vol. 57, No. 4, 01.12.2013, p. 317-326.

Research output: Contribution to journalReview article

@article{d27726d2e85d4f5a95eb15c1762ad840,
title = "Application of transport phenomena analysis technique to cerebrospinal fluid",
abstract = "The study of hydrocephalus and the modeling of cerebrospinal fluid flow have proceeded in the past using mathematical analysis that was very capable of prediction phenomenonologically but not well in physiologic parameters. In this paper, the basis of fluid dynamics at the physiologic state is explained using first established equations of transport phenomenon. Then, microscopic and molecular level techniques of modeling are described using porous media theory and chemical kinetic theory and then applied to cerebrospinal fluid (CSF) dynamics. Using techniques of transport analysis allows the field of cerebrospinal fluid dynamics to approach the level of sophistication of urine and blood transport. Concepts such as intracellular and intercellular pathways, compartmentalization, and tortuosity are associated with quantifiable parameters that are relevant to the anatomy and physiology of cerebrospinal fluid transport. The engineering field of transport phenomenon is rich and steeped in architectural, aeronautical, nautical, and more recently biological history. This paper summarizes and reviews the approaches that have been taken in the field of engineering and applies it to CSF flow.",
keywords = "Biomedical engineering, Cerebrospinal fluid, Hydrocephalus",
author = "Lam, {Cornelius H} and Hansen, {E. A.} and Hall, {W. A.} and Allison Hubel",
year = "2013",
month = "12",
day = "1",
language = "English (US)",
volume = "57",
pages = "317--326",
journal = "Journal of Neurosurgical Sciences",
issn = "0390-5616",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Application of transport phenomena analysis technique to cerebrospinal fluid

AU - Lam, Cornelius H

AU - Hansen, E. A.

AU - Hall, W. A.

AU - Hubel, Allison

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The study of hydrocephalus and the modeling of cerebrospinal fluid flow have proceeded in the past using mathematical analysis that was very capable of prediction phenomenonologically but not well in physiologic parameters. In this paper, the basis of fluid dynamics at the physiologic state is explained using first established equations of transport phenomenon. Then, microscopic and molecular level techniques of modeling are described using porous media theory and chemical kinetic theory and then applied to cerebrospinal fluid (CSF) dynamics. Using techniques of transport analysis allows the field of cerebrospinal fluid dynamics to approach the level of sophistication of urine and blood transport. Concepts such as intracellular and intercellular pathways, compartmentalization, and tortuosity are associated with quantifiable parameters that are relevant to the anatomy and physiology of cerebrospinal fluid transport. The engineering field of transport phenomenon is rich and steeped in architectural, aeronautical, nautical, and more recently biological history. This paper summarizes and reviews the approaches that have been taken in the field of engineering and applies it to CSF flow.

AB - The study of hydrocephalus and the modeling of cerebrospinal fluid flow have proceeded in the past using mathematical analysis that was very capable of prediction phenomenonologically but not well in physiologic parameters. In this paper, the basis of fluid dynamics at the physiologic state is explained using first established equations of transport phenomenon. Then, microscopic and molecular level techniques of modeling are described using porous media theory and chemical kinetic theory and then applied to cerebrospinal fluid (CSF) dynamics. Using techniques of transport analysis allows the field of cerebrospinal fluid dynamics to approach the level of sophistication of urine and blood transport. Concepts such as intracellular and intercellular pathways, compartmentalization, and tortuosity are associated with quantifiable parameters that are relevant to the anatomy and physiology of cerebrospinal fluid transport. The engineering field of transport phenomenon is rich and steeped in architectural, aeronautical, nautical, and more recently biological history. This paper summarizes and reviews the approaches that have been taken in the field of engineering and applies it to CSF flow.

KW - Biomedical engineering

KW - Cerebrospinal fluid

KW - Hydrocephalus

UR - http://www.scopus.com/inward/record.url?scp=84888797701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888797701&partnerID=8YFLogxK

M3 - Review article

VL - 57

SP - 317

EP - 326

JO - Journal of Neurosurgical Sciences

JF - Journal of Neurosurgical Sciences

SN - 0390-5616

IS - 4

ER -