Application of Snyder-Dolan classification scheme to the selection of "orthogonal" columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals - I. Isocratic elution

Wenzhe Fan, Yu Zhang, Peter W. Carr, Sarah C. Rutan, Melanie Dumarey, Adam P. Schellinger, Wayne Pritts

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Fourteen judiciously selected reversed phase columns were tested with 18 cationic drug solutes under the isocratic elution conditions advised in the Snyder-Dolan (S-D) hydrophobic subtraction method of column classification. The standard errors (S.E.) of the least squares regressions of log k′ vs. log k′ REF were obtained for a given column against a reference column and used to compare and classify columns based on their selectivity. The results are consistent with those obtained with a study of the 16 test solutes recommended by Snyder and Dolan. To the extent these drugs are representative, these results show that the S-D classification scheme is also generally applicable to pharmaceuticals under isocratic conditions. That is, those columns judged to be similar based on the 16 S-D solutes were similar based on the 18 drugs; furthermore those columns judged to have significantly different selectivities based on the 16 S-D probes appeared to be quite different for the drugs as well. Given that the S-D method has been used to classify more than 400 different types of reversed phases the extension to cationic drugs is a significant finding.

Original languageEnglish (US)
Pages (from-to)6587-6599
Number of pages13
JournalJournal of Chromatography A
Volume1216
Issue number38
DOIs
StatePublished - Sep 18 2009

Fingerprint

Drug Contamination
Street Drugs
Screening
Impurities
Pharmaceutical Preparations
Least-Squares Analysis

Keywords

  • "Orthogonal" separation
  • Basic drug
  • Column selectivity
  • Isocratic elution
  • Pharmaceutical analysis
  • Reversed phase
  • Snyder-Dolan classification scheme

Cite this

Application of Snyder-Dolan classification scheme to the selection of "orthogonal" columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals - I. Isocratic elution. / Fan, Wenzhe; Zhang, Yu; Carr, Peter W.; Rutan, Sarah C.; Dumarey, Melanie; Schellinger, Adam P.; Pritts, Wayne.

In: Journal of Chromatography A, Vol. 1216, No. 38, 18.09.2009, p. 6587-6599.

Research output: Contribution to journalArticle

@article{4981eda42faf4c9d9cfcb956a4be73e1,
title = "Application of Snyder-Dolan classification scheme to the selection of {"}orthogonal{"} columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals - I. Isocratic elution",
abstract = "Fourteen judiciously selected reversed phase columns were tested with 18 cationic drug solutes under the isocratic elution conditions advised in the Snyder-Dolan (S-D) hydrophobic subtraction method of column classification. The standard errors (S.E.) of the least squares regressions of log k′ vs. log k′ REF were obtained for a given column against a reference column and used to compare and classify columns based on their selectivity. The results are consistent with those obtained with a study of the 16 test solutes recommended by Snyder and Dolan. To the extent these drugs are representative, these results show that the S-D classification scheme is also generally applicable to pharmaceuticals under isocratic conditions. That is, those columns judged to be similar based on the 16 S-D solutes were similar based on the 18 drugs; furthermore those columns judged to have significantly different selectivities based on the 16 S-D probes appeared to be quite different for the drugs as well. Given that the S-D method has been used to classify more than 400 different types of reversed phases the extension to cationic drugs is a significant finding.",
keywords = "{"}Orthogonal{"} separation, Basic drug, Column selectivity, Isocratic elution, Pharmaceutical analysis, Reversed phase, Snyder-Dolan classification scheme",
author = "Wenzhe Fan and Yu Zhang and Carr, {Peter W.} and Rutan, {Sarah C.} and Melanie Dumarey and Schellinger, {Adam P.} and Wayne Pritts",
year = "2009",
month = "9",
day = "18",
doi = "10.1016/j.chroma.2009.07.048",
language = "English (US)",
volume = "1216",
pages = "6587--6599",
journal = "Journal of Chromatography",
issn = "0021-9673",
publisher = "Elsevier",
number = "38",

}

TY - JOUR

T1 - Application of Snyder-Dolan classification scheme to the selection of "orthogonal" columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals - I. Isocratic elution

AU - Fan, Wenzhe

AU - Zhang, Yu

AU - Carr, Peter W.

AU - Rutan, Sarah C.

AU - Dumarey, Melanie

AU - Schellinger, Adam P.

AU - Pritts, Wayne

PY - 2009/9/18

Y1 - 2009/9/18

N2 - Fourteen judiciously selected reversed phase columns were tested with 18 cationic drug solutes under the isocratic elution conditions advised in the Snyder-Dolan (S-D) hydrophobic subtraction method of column classification. The standard errors (S.E.) of the least squares regressions of log k′ vs. log k′ REF were obtained for a given column against a reference column and used to compare and classify columns based on their selectivity. The results are consistent with those obtained with a study of the 16 test solutes recommended by Snyder and Dolan. To the extent these drugs are representative, these results show that the S-D classification scheme is also generally applicable to pharmaceuticals under isocratic conditions. That is, those columns judged to be similar based on the 16 S-D solutes were similar based on the 18 drugs; furthermore those columns judged to have significantly different selectivities based on the 16 S-D probes appeared to be quite different for the drugs as well. Given that the S-D method has been used to classify more than 400 different types of reversed phases the extension to cationic drugs is a significant finding.

AB - Fourteen judiciously selected reversed phase columns were tested with 18 cationic drug solutes under the isocratic elution conditions advised in the Snyder-Dolan (S-D) hydrophobic subtraction method of column classification. The standard errors (S.E.) of the least squares regressions of log k′ vs. log k′ REF were obtained for a given column against a reference column and used to compare and classify columns based on their selectivity. The results are consistent with those obtained with a study of the 16 test solutes recommended by Snyder and Dolan. To the extent these drugs are representative, these results show that the S-D classification scheme is also generally applicable to pharmaceuticals under isocratic conditions. That is, those columns judged to be similar based on the 16 S-D solutes were similar based on the 18 drugs; furthermore those columns judged to have significantly different selectivities based on the 16 S-D probes appeared to be quite different for the drugs as well. Given that the S-D method has been used to classify more than 400 different types of reversed phases the extension to cationic drugs is a significant finding.

KW - "Orthogonal" separation

KW - Basic drug

KW - Column selectivity

KW - Isocratic elution

KW - Pharmaceutical analysis

KW - Reversed phase

KW - Snyder-Dolan classification scheme

UR - http://www.scopus.com/inward/record.url?scp=68949194582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949194582&partnerID=8YFLogxK

U2 - 10.1016/j.chroma.2009.07.048

DO - 10.1016/j.chroma.2009.07.048

M3 - Article

C2 - 19698948

AN - SCOPUS:68949194582

VL - 1216

SP - 6587

EP - 6599

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

IS - 38

ER -