Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

Cho Rong Kim, Jae Kyeom Kim, Eui Cheol Shin, Soo Jung Choi, Yoon Kyung Kwon, Youn Jung Kim, Chang Ju Kim, Gwi Gun Park, Cheung Seog Park, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

Abstract

Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.

Original languageEnglish (US)
Pages (from-to)807-811
Number of pages5
JournalJournal of the Korean Society for Applied Biological Chemistry
Volume57
Issue number6
DOIs
StatePublished - Dec 3 2014

Bibliographical note

Publisher Copyright:
© 2014, The Korean Society for Applied Biological Chemistry.

Keywords

  • Alzheimer’s disease
  • Rhodiola sachalinensis
  • acetylcholinesterase
  • response surface methodology
  • roseroot

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