Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

Cho Rong Kim; Jae Kyeom Kim; Eui Cheol Shin; Soo Jung Choi; Yoon Kyung Kwon; Youn Jung Kim; Chang Ju Kim; Gwi Gun Park; Cheung Seog Park; Dong Hoon Shin

doi:10.1007/s13765-014-4293-8

Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

Cho Rong Kim, Jae Kyeom Kim, Eui Cheol Shin, Soo Jung Choi, Yoon Kyung Kwon, Youn Jung Kim, Chang Ju Kim, Gwi Gun Park, Cheung Seog Park, Dong Hoon Shin

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

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Abstract

Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.

Original language	English (US)
Pages (from-to)	807-811
Number of pages	5
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	57
Issue number	6
DOIs	https://doi.org/10.1007/s13765-014-4293-8
State	Published - Dec 3 2014

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Publisher Copyright:
© 2014, The Korean Society for Applied Biological Chemistry.

Keywords

Alzheimer’s disease
Rhodiola sachalinensis
acetylcholinesterase
response surface methodology
roseroot

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10.1007/s13765-014-4293-8

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Kim, C. R., Kim, J. K., Shin, E. C., Choi, S. J., Kwon, Y. K., Kim, Y. J., Kim, C. J., Park, G. G., Park, C. S., & Shin, D. H. (2014). Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis. Journal of the Korean Society for Applied Biological Chemistry, 57(6), 807-811. https://doi.org/10.1007/s13765-014-4293-8

Kim, CR, Kim, JK, Shin, EC, Choi, SJ, Kwon, YK, Kim, YJ, Kim, CJ, Park, GG, Park, CS & Shin, DH 2014, 'Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis', Journal of the Korean Society for Applied Biological Chemistry, vol. 57, no. 6, pp. 807-811. https://doi.org/10.1007/s13765-014-4293-8

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abstract = "Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.",

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doi = "10.1007/s13765-014-4293-8",

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AU - Kim, Jae Kyeom

AU - Shin, Eui Cheol

AU - Choi, Soo Jung

AU - Kwon, Yoon Kyung

AU - Kim, Youn Jung

AU - Kim, Chang Ju

AU - Park, Gwi Gun

AU - Park, Cheung Seog

AU - Shin, Dong Hoon

PY - 2014/12/3

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KW - Rhodiola sachalinensis

KW - acetylcholinesterase

KW - response surface methodology

KW - roseroot

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Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

Abstract

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Keywords

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