TY - JOUR
T1 - Application of N,N‐dimethylformamide dineopentyl acetal for efficient anchoring of Nα‐9‐fluorenylmethyloxycarbonylamino‐acids as p‐alkoxybenzyl esters in solid‐phase peptide synthesis
AU - Albericio, Fernando
AU - Barany, George
PY - 1984/4
Y1 - 1984/4
N2 - The attachment of Fmoc‐amino acids onto p‐alkoxybenzyl alcohol resins via DCC‐DMAP coupling suffers from two different problems: formation of dimers and racemization. The use of N,N‐dimethylformamide dineopentyl acetal for the preparation of Fmoc‐aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.
AB - The attachment of Fmoc‐amino acids onto p‐alkoxybenzyl alcohol resins via DCC‐DMAP coupling suffers from two different problems: formation of dimers and racemization. The use of N,N‐dimethylformamide dineopentyl acetal for the preparation of Fmoc‐aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.
KW - N,N‐dimethylformamide dineopentyl acetal
KW - N‐9‐fluorenylmethyloxycarbonyl‐amino acids
KW - p‐alkoxybenzyl esters
KW - solid‐phase peptide synthesis
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U2 - 10.1111/j.1399-3011.1984.tb02729.x
DO - 10.1111/j.1399-3011.1984.tb02729.x
M3 - Article
C2 - 6547115
AN - SCOPUS:0021419322
SN - 0367-8377
VL - 23
SP - 342
EP - 349
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
IS - 4
ER -