Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs

E. Hanušovská, I. Dovinová, I. Tkáč, L. Novotný

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and vitro. The results of in vivo and in vitro 1H, 13C, 19F and 31P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.

Original languageEnglish (US)
Pages (from-to)187-197
Number of pages11
JournalNeoplasma
Volume45
Issue number4
StatePublished - Jan 1 1998

Keywords

  • Cancer therapy
  • Drug resistance
  • In vivo and in vitro NMR

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