Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs

E. Hanušovská; I. Dovinová; I. Tkáč; L. Novotný

Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs

E. Hanušovská, I. Dovinová, I. Tkáč, L. Novotný

Radiology

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and vitro. The results of in vivo and in vitro ¹H, ¹³C, ¹⁹F and ³¹P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.

Original language	English (US)
Pages (from-to)	187-197
Number of pages	11
Journal	Neoplasma
Volume	45
Issue number	4
State	Published - 1998

Keywords

Cancer therapy
Drug resistance
In vivo and in vitro NMR

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title = "Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs",

abstract = "Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and vitro. The results of in vivo and in vitro 1H, 13C, 19F and 31P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.",

keywords = "Cancer therapy, Drug resistance, In vivo and in vitro NMR",

author = "E. Hanu{\v s}ovsk{\'a} and I. Dovinov{\'a} and I. Tk{\'a}{\v c} and L. Novotn{\'y}",

year = "1998",

language = "English (US)",

volume = "45",

pages = "187--197",

journal = "Neoplasma",

issn = "0028-2685",

publisher = "AEPress, s.r.o.",

number = "4",

}

TY - JOUR

T1 - Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs

AU - Hanušovská, E.

AU - Dovinová, I.

AU - Tkáč, I.

AU - Novotný, L.

PY - 1998

Y1 - 1998

N2 - Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and vitro. The results of in vivo and in vitro 1H, 13C, 19F and 31P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.

AB - Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and vitro. The results of in vivo and in vitro 1H, 13C, 19F and 31P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.

KW - Cancer therapy

KW - Drug resistance

KW - In vivo and in vitro NMR

UR - http://www.scopus.com/inward/record.url?scp=0031740046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031740046&partnerID=8YFLogxK

M3 - Short survey

C2 - 9890660

AN - SCOPUS:0031740046

SN - 0028-2685

VL - 45

SP - 187

EP - 197

JO - Neoplasma

JF - Neoplasma

IS - 4

ER -

Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs

Abstract

Keywords

UN SDGs

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