Application of N-PLS calibration to the simultaneous determination of Cu2+, Cd2+ and Pb2+ using peptide modified electrochemical sensors

Edith Chow, Diako Ebrahimi, J. Justin Gooding, D. Brynn Hibbert

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The simultaneous determination of Cu2+, Cd2+ and Pb2+ is demonstrated at four modified gold electrodes using N-PLS calibration. Three of the electrodes were modified with the peptides Gly-Gly-His, γ-Glu-Cys Gly and human angiotensin I which were covalently attached to thioctic acid self-assembled monolayers and the fourth electrode was modified with thioctic acid only. Voltammetry at the modified electrodes in the presence of the three metal ions revealed one peak due to the reduction of copper and another due to the overlapping peaks of cadmium and lead which made quantification using conventional methods difficult. N-PLS was used to calibrate and predict trace concentrations (100 nM to 10 μM) of mixtures of Cu 2+, Cd2+ and Pb2+.

Original languageEnglish (US)
Pages (from-to)1051-1057
Number of pages7
JournalAnalyst
Volume131
Issue number9
DOIs
StatePublished - 2006

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