Application of indomethacin as a potentiator of lymphocyte blastogenesis in Brucella abortus exposed cattle

J. M B Kaneene, R. K. Anderson, D. W. Johnson, Charles C Muscoplat

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Abstract

Lymphocytes from Brucella abortus field strain infected, strain 19 vaccinated, non-exposed and field strain infected, but immunologically unresponsive cattle were incubated with B. abortus antigen and indomethacin. There were significant increases (P < 0.005) in the blastogenic responses, as measured by [3H] thymidine uptake, in cultures with indomethacin as compared to cultures without indomethacin. Lymphocyte blastogenic responses to B. abortus antigen were potentiated by indomethacin in both B. abortus exposed and non-exposed cultures. However, potentiation of sensitized lymphocyte blastogenic responses by indomethacin was significantly greater (P < 0.005) than that in non-exposed lymphocytes. Additionally, indomethacin significantly potentiated Brucella-induced lymphocyte blastogenic responses in lymphocytes from anergic cattle.

Original languageEnglish (US)
Pages (from-to)375-385
Number of pages11
JournalVeterinary immunology and immunopathology
Volume4
Issue number3
DOIs
StatePublished - Apr 1983

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS Supported in part by the U.S. Department of Agriculture, Veterinary Services and Science Education Administration, and the Minnesota Agricultural Experiment Station. We thank Diane Klausner for her technical help.

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