Abstract
Lymphocytes from Brucella abortus field strain infected, strain 19 vaccinated, non-exposed and field strain infected, but immunologically unresponsive cattle were incubated with B. abortus antigen and indomethacin. There were significant increases (P < 0.005) in the blastogenic responses, as measured by [3H] thymidine uptake, in cultures with indomethacin as compared to cultures without indomethacin. Lymphocyte blastogenic responses to B. abortus antigen were potentiated by indomethacin in both B. abortus exposed and non-exposed cultures. However, potentiation of sensitized lymphocyte blastogenic responses by indomethacin was significantly greater (P < 0.005) than that in non-exposed lymphocytes. Additionally, indomethacin significantly potentiated Brucella-induced lymphocyte blastogenic responses in lymphocytes from anergic cattle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-385 |
| Number of pages | 11 |
| Journal | Veterinary immunology and immunopathology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1983 |
Bibliographical note
Funding Information:ACKNOWLEDGEMENTS Supported in part by the U.S. Department of Agriculture, Veterinary Services and Science Education Administration, and the Minnesota Agricultural Experiment Station. We thank Diane Klausner for her technical help.