Application of HMBC and HMQC-TOCSY NMR methods to assign the structures of bicyclic-peptide mimetics

D. Andre D’avignon, Cathleen E. Hanau, Yvette M. Fobian, Kevin D. Moeller

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The structures of representative bicyclic peptides are confirmed through the NMR methods of HMBC and HMQC-TOCSY. Complete assignment of proton and carbon resonances is afforded by these two-dimensional NMR methods. HMQC-TOCSY is especially useful for assigning spectra in molecules having extensive proton spin systems and in establishing connectivities between protonated carbons. Long-range proton-carbon connectivities obtained by HMBC confirm structure in molecules containing heteroatoms or non-protonated carbons that interrupt proton spin systems.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalJournal of Coordination Chemistry
Volume32
Issue number1-3
DOIs
StatePublished - Jun 1 1994
Externally publishedYes

Keywords

  • HMBC
  • HMQC-TOCSY
  • NMR
  • bicyclic peptides

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