Apparent protein kinase activity in oligodendroglial chromatin after chronic morphine treatment

Kazuta Oguri, Nancy M. Lee, Horace H. Loh

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The oligodendroglial nuclei were purified from mouse brain with more than 97 per cent homogeneity. Cyclic AMP-independent phosphorylation of non-histone protein in oligodendroglial chromatin was studied. Morphine sulfate, in vitro, had no effect on phosphorylation. However, chronic morphine treatment resulted in an increase of phosphorylation in high molecular weight regions of sodium dodecylsulfate (SDS) electrophoresis gel. The increase was not the result of a decrease in phosphoprotein phosphatase activity.

Original languageEnglish (US)
Pages (from-to)2371-2376
Number of pages6
JournalBiochemical Pharmacology
Volume25
Issue number21
DOIs
StatePublished - Nov 1 1976

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