Apoptosis induction by arsenic: Mechanisms of action and possible clinical applications for treating therapy-resistant cancers

Ann Bode, Zigang Dong

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Arsenic, a known carcinogen, may be useful in cancer treatment. Arsenic may be effective in counteracting drug resistance because it appears to induce apoptosis in tumor cells independently of p53 activation, thereby allowing it to be directed against p53-defective cancers. The role of MAP kinases in arsenic-induced apoptosis in tumor cells is important and may be influenced by reactive oxygen species or glutathione. This review focuses on recent findings from this and other laboratories regarding the mechanism(s) of arsenic-induced apoptosis in tumor cells and considers their relevance in the clinical treatment of therapy-resistant cancers. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalDrug Resistance Updates
Volume3
Issue number1
DOIs
StatePublished - Feb 2000

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