Apoptosis and heart failure: Clinical relevance and therapeutic target

Shaila Garg, Jagat Narula, Y. Chandrashekhar

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

Heart failure is the final common pathway of diverse ethiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditionnal explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progressiom of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Volume38
Issue number1
DOIs
StatePublished - Jan 2005

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Apoptosis
  • Clinical therapy
  • Heart failure
  • Review

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