Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction data from the Third National Health and Nutrition Examination Survey

Adnan I. Qureshi, Wayne H. Giles, Janet B. Croft, Lee R. Guterman, L. Nelson Hopkins

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined. Material/Methods: We evaluated the association between plasma concentrations of APO A-1 and APO B with a physician diagnosis of stroke (n = 153), and electrocardiogram evidence or physician diagnosis of myocardial infarction (n=379), in a nationally representative sample of 3,696 US adults aged ≥40 years who participated in the Third National Health and Nutrition Examination Survey. Multivariate logistic regression analyses were used to investigate these relationships. Results: After adjusting for differences in age, gender, race/ethnicity, education, hypertension, cholesterol, body mass index, and cigarette smoking, the upper quartile of APO A-1 (≥ 161 mg/dl) when compared with the lowest quartile (< 126 mg/dL) was inversely associated with the likelihood of myocardial infarction (Odds Ratio [OR], 0.6; 95% Confidence Interval [CI] 0.4-0.9) but not stroke. APO B concentrations were not associated with either myocardial infarction or stroke. However, an APO A-1 to B ratio ≥ 1.59 when compared with a ratio ≤ 1.04 was associated with a decreased likelihood of myocardial infarction (OR, 0.3; 95% CI, 0.2-0.6); and stroke (OR 0.4, 95% CI, 0.2-1.0). Conclusion: Higher APO A-1 concentrations were associated with a decreased likelihood for myocardial infarction but not for stroke. The APO A-1 to B ratio was inversely associated with both myocardial infarction and stroke and may be an important protective clinical marker for atherosclerosis.

Original languageEnglish (US)
Pages (from-to)CR311-CR316
JournalMedical Science Monitor
Volume8
Issue number5
StatePublished - Jun 18 2002

Keywords

  • Apolipoproteins
  • Myocardial infarction
  • Stroke

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