Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Hector M. González; Wassim Tarraf; Xueqiu Jian; Priscilla M. Vásquez; Robert Kaplan; Bharat Thyagarajan; Martha Daviglus; Melissa Lamar; Linda C. Gallo; Donglin Zeng; Myriam Fornage

doi:10.1038/s41598-018-35573-3

Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Hector M. González, Wassim Tarraf, Xueqiu Jian, Priscilla M. Vásquez, Robert Kaplan, Bharat Thyagarajan, Martha Daviglus, Melissa Lamar, Linda C. Gallo, Donglin Zeng, Myriam Fornage

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.

Original language	English (US)
Article number	17578
Journal	Scientific reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-35573-3
State	Published - Dec 1 2018

Bibliographical note

Funding Information:
The authors thank the staff and participants of HCHS/SOL for their important contributions. Investigators website - http://www.cscc.unc.edu/hchs/ Guarantor’s statement: Dr. Hector M. González and Myriam Fornage are the guarantors of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs González, Fornage, Jian, and Tarraf receive support for this work from the National Institute of Aging grant numbers R01-AG048642. The Hispanic Community Health Study/Study of Hispanic/Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/ Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements. This work was supported by the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

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© 2018, The Author(s).

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González, H. M., Tarraf, W., Jian, X., Vásquez, P. M., Kaplan, R., Thyagarajan, B., Daviglus, M., Lamar, M., Gallo, L. C., Zeng, D., & Fornage, M. (2018). Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). Scientific reports, 8(1), [17578]. https://doi.org/10.1038/s41598-018-35573-3

González, HM, Tarraf, W, Jian, X, Vásquez, PM, Kaplan, R, Thyagarajan, B, Daviglus, M, Lamar, M, Gallo, LC, Zeng, D & Fornage, M 2018, 'Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)', Scientific reports, vol. 8, no. 1, 17578. https://doi.org/10.1038/s41598-018-35573-3

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abstract = "The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer{\textquoteright}s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.",

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note = "Funding Information: The authors thank the staff and participants of HCHS/SOL for their important contributions. Investigators website - http://www.cscc.unc.edu/hchs/ Guarantor{\textquoteright}s statement: Dr. Hector M. Gonz{\'a}lez and Myriam Fornage are the guarantors of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Gonz{\'a}lez, Fornage, Jian, and Tarraf receive support for this work from the National Institute of Aging grant numbers R01-AG048642. The Hispanic Community Health Study/Study of Hispanic/Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/ Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements. This work was supported by the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2018, The Author(s).",

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AU - Kaplan, Robert

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AU - Daviglus, Martha

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AU - Gallo, Linda C.

AU - Zeng, Donglin

AU - Fornage, Myriam

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Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Abstract

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