We determined if the apolipoprotein E(APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL2-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL2-C with exercise training than APO E3 and E4 men (HDL-C, 8 ± 4 v 3 ± 1 v 2 ± 1 mg/dL; HDL2-C, 5 ± 3 v 1 ± 1 v - 1 ± 1 mg/dL; mean ± SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL2-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL2-C increases with endurance exercise training.
Bibliographical noteFunding Information:
From the Department of Kinesiology, University of Maryland, College Park," Dlvzsion of Gerontology, University of Maryland School of Medicine, Baltimore; Baltimore Veterans Affairs (VA) Medzcal Center Geriatric Research, Education, and Clinical Center (GRECC), Baltimore, MD, and Department of Human Genetics, University of Pittsburgh Graduate School of Pubhc Health, Pittsburgh, PA. Submitted October 3, 1998; accepted March 23, 1999. Supported by a grant fpvm the Maryland Affiliate of the American Heart Association, a VA Regional Advisory Group Award, Natzonal hzstitutes of Health (NIH) Grants No. PO1-AG4402, ROl-AG07660, KO7-AGO0608, RO1-HL39107, and RO1-HL45778, and the Baltimore VA Medical Center GRECC and in part by N1H National Research Servwe Award No. AG-05555 (D.R.D.) and NIA intramural funds from the Laboratory of Chnical Physiology, Metabolism Section, Gerontology Research Center (J.D.S.). Address reprint requests to James Hagberg, PhD. Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. Copyright © 1999 by WB. Saunders Company 0026-0495/99/4808-0001510.00/0