Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men

James M. Hagberg; Robert E. Ferrell; Leslie I. Katzel; Donald R. Dengel; John D. Sorkin; Andrew P. Goldberg

doi:10.1016/S0026-0495(99)90185-3

Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL₂-cholesterol levels in overweight men

James M. Hagberg, Robert E. Ferrell, Leslie I. Katzel, Donald R. Dengel, John D. Sorkin, Andrew P. Goldberg

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

We determined if the apolipoprotein E(APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL₂-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL₂-C with exercise training than APO E3 and E4 men (HDL-C, 8 ± 4 v 3 ± 1 v 2 ± 1 mg/dL; HDL₂-C, 5 ± 3 v 1 ± 1 v - 1 ± 1 mg/dL; mean ± SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL₂-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL₂-C increases with endurance exercise training.

Original language	English (US)
Pages (from-to)	943-945
Number of pages	3
Journal	Metabolism: clinical and experimental
Volume	48
Issue number	8
DOIs	https://doi.org/10.1016/S0026-0495(99)90185-3
State	Published - 1999

Bibliographical note

Funding Information:
From the Department of Kinesiology, University of Maryland, College Park," Dlvzsion of Gerontology, University of Maryland School of Medicine, Baltimore; Baltimore Veterans Affairs (VA) Medzcal Center Geriatric Research, Education, and Clinical Center (GRECC), Baltimore, MD, and Department of Human Genetics, University of Pittsburgh Graduate School of Pubhc Health, Pittsburgh, PA. Submitted October 3, 1998; accepted March 23, 1999. Supported by a grant fpvm the Maryland Affiliate of the American Heart Association, a VA Regional Advisory Group Award, Natzonal hzstitutes of Health (NIH) Grants No. PO1-AG4402, ROl-AG07660, KO7-AGO0608, RO1-HL39107, and RO1-HL45778, and the Baltimore VA Medical Center GRECC and in part by N1H National Research Servwe Award No. AG-05555 (D.R.D.) and NIA intramural funds from the Laboratory of Chnical Physiology, Metabolism Section, Gerontology Research Center (J.D.S.). Address reprint requests to James Hagberg, PhD. Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. Copyright © 1999 by WB. Saunders Company 0026-0495/99/4808-0001510.00/0

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@article{5b273f0c52884a75bbeae4f6a0da6584,

title = "Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men",

abstract = "We determined if the apolipoprotein E(APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL2-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL2-C with exercise training than APO E3 and E4 men (HDL-C, 8 ± 4 v 3 ± 1 v 2 ± 1 mg/dL; HDL2-C, 5 ± 3 v 1 ± 1 v - 1 ± 1 mg/dL; mean ± SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL2-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL2-C increases with endurance exercise training.",

author = "Hagberg, {James M.} and Ferrell, {Robert E.} and Katzel, {Leslie I.} and Dengel, {Donald R.} and Sorkin, {John D.} and Goldberg, {Andrew P.}",

note = "Funding Information: From the Department of Kinesiology, University of Maryland, College Park,{"} Dlvzsion of Gerontology, University of Maryland School of Medicine, Baltimore; Baltimore Veterans Affairs (VA) Medzcal Center Geriatric Research, Education, and Clinical Center (GRECC), Baltimore, MD, and Department of Human Genetics, University of Pittsburgh Graduate School of Pubhc Health, Pittsburgh, PA. Submitted October 3, 1998; accepted March 23, 1999. Supported by a grant fpvm the Maryland Affiliate of the American Heart Association, a VA Regional Advisory Group Award, Natzonal hzstitutes of Health (NIH) Grants No. PO1-AG4402, ROl-AG07660, KO7-AGO0608, RO1-HL39107, and RO1-HL45778, and the Baltimore VA Medical Center GRECC and in part by N1H National Research Servwe Award No. AG-05555 (D.R.D.) and NIA intramural funds from the Laboratory of Chnical Physiology, Metabolism Section, Gerontology Research Center (J.D.S.). Address reprint requests to James Hagberg, PhD. Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. Copyright {\textcopyright} 1999 by WB. Saunders Company 0026-0495/99/4808-0001510.00/0",

year = "1999",

doi = "10.1016/S0026-0495(99)90185-3",

language = "English (US)",

volume = "48",

pages = "943--945",

journal = "Metabolism: clinical and experimental",

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T1 - Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men

AU - Hagberg, James M.

AU - Ferrell, Robert E.

AU - Katzel, Leslie I.

AU - Dengel, Donald R.

AU - Sorkin, John D.

AU - Goldberg, Andrew P.

N1 - Funding Information: From the Department of Kinesiology, University of Maryland, College Park," Dlvzsion of Gerontology, University of Maryland School of Medicine, Baltimore; Baltimore Veterans Affairs (VA) Medzcal Center Geriatric Research, Education, and Clinical Center (GRECC), Baltimore, MD, and Department of Human Genetics, University of Pittsburgh Graduate School of Pubhc Health, Pittsburgh, PA. Submitted October 3, 1998; accepted March 23, 1999. Supported by a grant fpvm the Maryland Affiliate of the American Heart Association, a VA Regional Advisory Group Award, Natzonal hzstitutes of Health (NIH) Grants No. PO1-AG4402, ROl-AG07660, KO7-AGO0608, RO1-HL39107, and RO1-HL45778, and the Baltimore VA Medical Center GRECC and in part by N1H National Research Servwe Award No. AG-05555 (D.R.D.) and NIA intramural funds from the Laboratory of Chnical Physiology, Metabolism Section, Gerontology Research Center (J.D.S.). Address reprint requests to James Hagberg, PhD. Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. Copyright © 1999 by WB. Saunders Company 0026-0495/99/4808-0001510.00/0

PY - 1999

Y1 - 1999

N2 - We determined if the apolipoprotein E(APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL2-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL2-C with exercise training than APO E3 and E4 men (HDL-C, 8 ± 4 v 3 ± 1 v 2 ± 1 mg/dL; HDL2-C, 5 ± 3 v 1 ± 1 v - 1 ± 1 mg/dL; mean ± SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL2-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL2-C increases with endurance exercise training.

AB - We determined if the apolipoprotein E(APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL2-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL2-C with exercise training than APO E3 and E4 men (HDL-C, 8 ± 4 v 3 ± 1 v 2 ± 1 mg/dL; HDL2-C, 5 ± 3 v 1 ± 1 v - 1 ± 1 mg/dL; mean ± SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL2-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL2-C increases with endurance exercise training.

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