Apoferritin as a bionanomaterial to facilitate the electron transfer reactivity of hemoglobin and the catalytic activity towards hydrogen peroxide

Guifang Chen, Xiaoli Zhu, Fanben Meng, Zhiguo Yu, Genxi Li

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this report, apoferritin as a stable bionanomaterial was modified with hemoglobin on pyrolytic graphite electrode. Rapid electron transfer reactions of hemoglobin were achieved with the help of apoferritin in a large pH range. Moreover, hemoglobin as an enzyme exhibits fine electrocatalytic activity towards the reaction of hydrogen peroxide, and a wide concentration range of linear relationship between the reduction peak current and the concentration of hydrogen peroxide has been obtained with a higher upper detection limit, which may be further developed for a hydrogen peroxide biosensor. Therefore, a new property of apoferritin is explored, in which apoferritin works as a bionanomaterial to be an accelerant of the electron transfer of Hb and a stabilizer to retain the catalytic ability of the protein under mal-condition.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalBioelectrochemistry
Volume72
Issue number1
DOIs
StatePublished - Feb 2008

Bibliographical note

Funding Information:
This work is supported by the National Natural Science Foundation of China (Grant No. 90406005, 20575028) and the Program for New Century Excellent Talents in University, the Chinese Ministry of Education (NCET-04-0452).

Keywords

  • Apoferritin
  • Bionanomaterial
  • Hemoglobin
  • Hydrogen peroxide

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