APOE ε4 and Alzheimer's disease risk in Vietnamese populations

Adam D. Block; Ashley Petersen; Adam Hansen; Matti Matheson; Phuong Anh Thi Nguyen; Viet Luc Tran; Binh Thanh Nguyen; Binh Thanh Nguyen; Binh Thanh Thi Nguyen; Huong Thanh Tran; Trung Anh Nguyen; Thang Pham; Ladson Hinton; Huong Nguyen; William G. Mantyh

doi:10.1177/25424823251334066

APOE ε4 and Alzheimer's disease risk in Vietnamese populations

Adam D. Block
, Ashley Petersen
, Adam Hansen
, Matti Matheson
, Phuong Anh Thi Nguyen
, Viet Luc Tran
, Binh Thanh Nguyen
, Binh Thanh Nguyen
, Binh Thanh Thi Nguyen
, Huong Thanh Tran
, Trung Anh Nguyen
, Thang Pham
, Ladson Hinton
, Huong Nguyen
, William G. Mantyh

Research output: Contribution to journal › Article › peer-review

Abstract

APOE ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), but this risk varies with ancestry. Little is known about the APOE ε4-AD risk in Vietnamese populations. We found two Vietnamese-language articles that included full APOE genotype data in Vietnamese AD dementia participants (N = 60) and controls (N = 30). APOE ε4/ε3 versus ε3/ε3 was associated with an odds ratio of 8.96 (95% confidence interval: 2.87–32.4) for AD dementia. Despite wide confidence intervals, the APOE ε4-AD odds ratio in Vietnamese populations appears similar to Korean and Japanese populations, who have the highest known APOE ε4-AD odds ratio.

Original language	English (US)
Journal	Journal of Alzheimer's Disease Reports
Volume	9
DOIs	https://doi.org/10.1177/25424823251334066
State	Published - Jan 1 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://uk.sagepub.com/en-gb/eur/open-access-at-sage).

Keywords

APOE4
Alzheimer's disease
Vietnam
global health

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10.1177/25424823251334066

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abstract = "APOE ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), but this risk varies with ancestry. Little is known about the APOE ε4-AD risk in Vietnamese populations. We found two Vietnamese-language articles that included full APOE genotype data in Vietnamese AD dementia participants (N = 60) and controls (N = 30). APOE ε4/ε3 versus ε3/ε3 was associated with an odds ratio of 8.96 (95\% confidence interval: 2.87–32.4) for AD dementia. Despite wide confidence intervals, the APOE ε4-AD odds ratio in Vietnamese populations appears similar to Korean and Japanese populations, who have the highest known APOE ε4-AD odds ratio.",

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T1 - APOE ε4 and Alzheimer's disease risk in Vietnamese populations

AU - Block, Adam D.

AU - Petersen, Ashley

AU - Hansen, Adam

AU - Matheson, Matti

AU - Nguyen, Phuong Anh Thi

AU - Tran, Viet Luc

AU - Nguyen, Binh Thanh

AU - Nguyen, Binh Thanh Thi

AU - Tran, Huong Thanh

AU - Nguyen, Trung Anh

AU - Pham, Thang

AU - Hinton, Ladson

AU - Nguyen, Huong

AU - Mantyh, William G.

N1 - Publisher Copyright: © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://uk.sagepub.com/en-gb/eur/open-access-at-sage).

PY - 2025/1/1

Y1 - 2025/1/1

N2 - APOE ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), but this risk varies with ancestry. Little is known about the APOE ε4-AD risk in Vietnamese populations. We found two Vietnamese-language articles that included full APOE genotype data in Vietnamese AD dementia participants (N = 60) and controls (N = 30). APOE ε4/ε3 versus ε3/ε3 was associated with an odds ratio of 8.96 (95% confidence interval: 2.87–32.4) for AD dementia. Despite wide confidence intervals, the APOE ε4-AD odds ratio in Vietnamese populations appears similar to Korean and Japanese populations, who have the highest known APOE ε4-AD odds ratio.

AB - APOE ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), but this risk varies with ancestry. Little is known about the APOE ε4-AD risk in Vietnamese populations. We found two Vietnamese-language articles that included full APOE genotype data in Vietnamese AD dementia participants (N = 60) and controls (N = 30). APOE ε4/ε3 versus ε3/ε3 was associated with an odds ratio of 8.96 (95% confidence interval: 2.87–32.4) for AD dementia. Despite wide confidence intervals, the APOE ε4-AD odds ratio in Vietnamese populations appears similar to Korean and Japanese populations, who have the highest known APOE ε4-AD odds ratio.

KW - APOE4

KW - Alzheimer's disease

KW - Vietnam

KW - global health

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VL - 9

JO - Journal of Alzheimer's Disease Reports

JF - Journal of Alzheimer's Disease Reports

ER -

APOE ε4 and Alzheimer's disease risk in Vietnamese populations

Abstract

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