APOBECs and their role in proviral DNA synthesis

John S. Albin, Reuben S. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The human APOBEC3 subfamily consists of seven DNA cytosine deaminases that act on single-stranded cDNA during HIV reverse transcription. The net effect of these enzymes is the restriction of viral infectivity due to the inhibition of reverse transcription and to the hypermutation of those genomes that complete cDNA synthesis and integration. In this chapter, we introduce the APOBEC3 proteins in historical context as a prelude to the consideration of evidence for their deaminase-dependent and deaminase-independent mechanisms of antiviral action. We also consider how editing of the viral genome by APOBEC3 proteins may alter the coding capacity and pathogenic potential of HIV by contributing to the inherently error-prone replication process and to the overall high level of HIV genetic variation.

Original languageEnglish (US)
Title of host publicationHuman Immunodeficiency Virus Reverse Transcriptase
Subtitle of host publicationA Bench-to-Bedside Success
PublisherSpringer New York
Pages253-280
Number of pages28
ISBN (Electronic)9781461472919
ISBN (Print)1461472903, 9781461472902
DOIs
StatePublished - Nov 1 2013

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