APOBEC3F determinants of HIV-1 Vif sensitivity

Allison M. Land, Nadine M. Shaban, Leah Evans, Judd F. Hultquist, John S. Albin, Reuben S. Harris

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

Original languageEnglish (US)
Pages (from-to)12923-12927
Number of pages5
JournalJournal of virology
Volume88
Issue number21
DOIs
StatePublished - 2014

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