APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

Keyphrases

• APOBEC3 100%
• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Primary Function 100%
• THP1 100%
• Myeloid Cell Lines 100%
• Virion Infectivity 100%
• Infectivity 33%
• THP-1 Cells 33%
• APOBEC3 Proteins 26%
• Virus 20%
• CD4+ T Lymphocytes 20%
• Antiviral Activity 13%
• HIV-1 Restriction 13%
• HIV-1 Production 13%
• Protein Expression 6%
• Cellular Proteins 6%
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 6%
• Macrophages 6%
• HIV-1 Replication 6%
• Cellular Targets 6%
• Polypeptide 6%
• Ablating 6%
• Viral Replication 6%
• Infected Cells 6%
• Null Cell 6%
• Innate Antiviral 6%
• Neutralization Activity 6%
• Essential Targets 6%
• Apolipoprotein B mRNA Editing Enzyme 6%
• PPP2R5 6%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Virion 100%
• Bone Marrow Culture 100%
• Infection 100%
• CD4+ T Lymphocyte 15%
• Defective Interfering Particle 10%
• Macrophage 5%
• Virus 5%
• Viral Replication 5%
• Neutralization 5%
• Null Cell 5%
• HIV Type 1 5%
• Protein Expression 5%
• Antiviral Activity 5%
• Clustered Regularly Interspaced Short Palindromic Repeat 5%
• Haplotype 5%
• Wild Type 5%
• Apolipoprotein B 5%
• Replication 5%