Aortic valve pathophysiology during left ventricular assist device support

Ranjit John, Katie Mantz, Peter Eckman, Alan Rose, Karen May-Newman

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


The increased applicability and excellent results with left ventricular assist devices (LVADs) have revolutionized the available treatment options for patients with advanced heart failure. Pre-existing valve abnormalities are common in this population, and subsequent development of valve abnormalities after LVAD placement is also often noted. Although native mitral and tricuspid valve disease is more common in heart failure patients before LVAD placement, aortic valves are much more likely to generate abnormal pathophysiology in the LVAD patient during as well as after LVAD placement. The aim of this comprehensive review is to review aortic valve function in LVAD patients and highlight the consideration of pre-existing valve disease on patient treatment at the time of LVAD implant. The basis for structural changes leading to valve pathophysiology during and after LVAD placement will be described, providing a basis for improved clinical understanding and new strategies to prevent these conditions.

Original languageEnglish (US)
Pages (from-to)1321-1329
Number of pages9
JournalJournal of Heart and Lung Transplantation
Issue number12
StatePublished - Dec 2010

Bibliographical note

Funding Information:
Ranjit John has a research grant from Thoratec, Inc . None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.


  • aortic valve
  • heart failure
  • ventricular assist device


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