Anxious responses to predictable and unpredictable aversive events

Christian Grillon, Johanna P. Baas, Shmuel Lissek, Kathryn Smith, Jean Milstein

Research output: Contribution to journalArticlepeer-review

199 Scopus citations

Abstract

Anxiety induced by 2 types of predictable and unpredictable aversive stimuli, an unpleasant shock or a less aversive airblast to the larynx, were investigated in a between-group design. Participants anticipated predictable (signaled) or unpredictable (not signaled) aversive events, or no aversive event. Unpredictable, relative to predictable, contexts potentiated the startle reflex in the shock group but not in the airblast group. These data suggest that unpredictability can lead to a sustained level of anxiety only when the pending stimulus is sufficiently aversive. Because predictable and unpredictable danger may induce different types of aversive responses, the proposed design can serve as a useful tool for studying the neurobiology and psychopharmacology of fear and anxiety.

Original languageEnglish (US)
Pages (from-to)916-924
Number of pages9
JournalBehavioral Neuroscience
Volume118
Issue number5
DOIs
StatePublished - Oct 1 2004

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