Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene

An Li Wang, Owen Y. Chao, Yi-Mei (Amy) Yang, Svenja V. Trossbach, Christian P. Müller, Carsten Korth, Joseph P. Huston, Maria Angelica de Souza Silva

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (EPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). TgDISC1 rats showed enhanced anxiety behavior in the EPM and an impairment in attention-like/short-term working-memory in the SAB. However, tgDISC1 animals showed no locomotor impairments or depression-like behavior in the OF and FST. These results suggest that DISC1 overexpression leads to higher anxiety level and an attention-like/working-memory deficit. These findings may expand the causal role of DISC1 in its contribution to multiple symptom dimensions of psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume179
DOIs
StatePublished - Apr 1 2019

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Short-Term Memory
Rats
Schizophrenia
Genes
Data storage equipment
Anxiety
Dopamine
Animals
Psychiatry
Depression
Neurobehavioral Manifestations
Genetically Modified Animals
Memory Disorders
Locomotion
Cognition
Learning
Phenotype
Mutation

Keywords

  • Anxiogenic behavior
  • Attention
  • Cognitive dysfunction
  • DISC1
  • Working memory

PubMed: MeSH publication types

  • Journal Article

Cite this

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene. / Wang, An Li; Chao, Owen Y.; Yang, Yi-Mei (Amy); Trossbach, Svenja V.; Müller, Christian P.; Korth, Carsten; Huston, Joseph P.; de Souza Silva, Maria Angelica.

In: Pharmacology Biochemistry and Behavior, Vol. 179, 01.04.2019, p. 73-79.

Research output: Contribution to journalArticle

Wang, An Li ; Chao, Owen Y. ; Yang, Yi-Mei (Amy) ; Trossbach, Svenja V. ; Müller, Christian P. ; Korth, Carsten ; Huston, Joseph P. ; de Souza Silva, Maria Angelica. / Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene. In: Pharmacology Biochemistry and Behavior. 2019 ; Vol. 179. pp. 73-79.
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