Antiviral nucleoside drug delivery via amino acid phosphoramidates

Carston R. Wagner, Shu Ling Chang, George W. Griesgraber, Heng Song, Edward J. McIntee, Cheryl L. Zimmerman

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Stable and water soluble amino acid phosphomonoester amidates of AZT were synthesized and shown to have potent anti-HIV-1 activity. Intracellular and cell extract metabolism studies revealed that these compounds are likely to be enzymatically converted to the corresponding monophosphates. In addition, we have shown that the half life and tissue distribution of a phosphoramidate of AZT is 5 and 10-fold greater, respectively, than AZT.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalNucleosides and Nucleotides
Volume18
Issue number4-5
DOIs
StatePublished - Jan 1 1999

Fingerprint Dive into the research topics of 'Antiviral nucleoside drug delivery via amino acid phosphoramidates'. Together they form a unique fingerprint.

  • Cite this

    Wagner, C. R., Chang, S. L., Griesgraber, G. W., Song, H., McIntee, E. J., & Zimmerman, C. L. (1999). Antiviral nucleoside drug delivery via amino acid phosphoramidates. Nucleosides and Nucleotides, 18(4-5), 913-919. https://doi.org/10.1080/15257779908041599