Antiviral nucleoside drug delivery via amino acid phosphoramidates

Carston R. Wagner, Shu Ling Chang, George W. Griesgraber, Heng Song, Edward J. McIntee, Cheryl L. Zimmerman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Stable and water soluble amino acid phosphomonoester amidates of AZT were synthesized and shown to have potent anti-HIV-1 activity. Intracellular and cell extract metabolism studies revealed that these compounds are likely to be enzymatically converted to the corresponding monophosphates. In addition, we have shown that the half life and tissue distribution of a phosphoramidate of AZT is 5 and 10-fold greater, respectively, than AZT.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalNucleosides and Nucleotides
Volume18
Issue number4-5
DOIs
StatePublished - Jan 1 1999

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Tissue Distribution
Cell Extracts
Drug delivery
Nucleosides
Metabolism
Antiviral Agents
Half-Life
HIV-1
Tissue
Amino Acids
Water
phosphoramidic acid

Cite this

Wagner, C. R., Chang, S. L., Griesgraber, G. W., Song, H., McIntee, E. J., & Zimmerman, C. L. (1999). Antiviral nucleoside drug delivery via amino acid phosphoramidates. Nucleosides and Nucleotides, 18(4-5), 913-919. https://doi.org/10.1080/15257779908041599

Antiviral nucleoside drug delivery via amino acid phosphoramidates. / Wagner, Carston R.; Chang, Shu Ling; Griesgraber, George W.; Song, Heng; McIntee, Edward J.; Zimmerman, Cheryl L.

In: Nucleosides and Nucleotides, Vol. 18, No. 4-5, 01.01.1999, p. 913-919.

Research output: Contribution to journalArticle

Wagner, CR, Chang, SL, Griesgraber, GW, Song, H, McIntee, EJ & Zimmerman, CL 1999, 'Antiviral nucleoside drug delivery via amino acid phosphoramidates', Nucleosides and Nucleotides, vol. 18, no. 4-5, pp. 913-919. https://doi.org/10.1080/15257779908041599
Wagner, Carston R. ; Chang, Shu Ling ; Griesgraber, George W. ; Song, Heng ; McIntee, Edward J. ; Zimmerman, Cheryl L. / Antiviral nucleoside drug delivery via amino acid phosphoramidates. In: Nucleosides and Nucleotides. 1999 ; Vol. 18, No. 4-5. pp. 913-919.
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