Antitumor and antioxidant potential of Tragia Plukenetii R.Smith on Ehrlich ascites carcinoma in mice

Meenakshi Sundaram Muthuraman, Sudarsanam Dorairaj, Parthasarathy Rangarajan, Brindha Pemaiah

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

This investigation aims to evaluate the antitumour and antioxidant potential of the ethanol extract of Tragia Plukenetii R.Smith (ETP) on Ehrlich ascites carcinoma (EAC) tumor model. Tumor was induced in mice by intraperitoneal injection of EAC cells (2×106 cells/mouse). Ethanol extract of T. Plukenetii (ETP) was administered to the experimental animals at the dose levels of 100, 200 and 300 mg/kg/day after 24 h of tumour inoculation. The antitumour effect of ETP was evaluated by assessing in vitro cytotoxicity, survival time, hematological and antioxidant parameters. Oral administration of ETP increased the survival time of the EAC bearing mice. The ETP brought back the altered levels of the hematological and antioxidant parameters in a dose dependent manner in EAC bearing mice. The results were comparable to that of the result obtained from the animals treated with the standard drug 5-flurouracil (20 mg/kg.bw). Thus present study revealed that ETP possessed significant antitumor and antioxidant activity.

Original languageEnglish (US)
Pages (from-to)3527-3530
Number of pages4
JournalAfrican Journal of Biotechnology
Volume7
Issue number20
StatePublished - Oct 20 2008
Externally publishedYes

Keywords

  • Antioxidant
  • Ehrlich ascites carcinoma
  • Hematological parameters
  • Tragia Plukenetii
  • Tumour growth response

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