Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake

Willis K. Samson, Ann M. Bode, Tonya C. Murphy, Zachary T. Resch

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.

Original languageEnglish (US)
Pages (from-to)164-167
Number of pages4
JournalBrain Research
Volume818
Issue number1
DOIs
StatePublished - Feb 6 1999

Bibliographical note

Funding Information:
This work was supported by a grant from the Max Baer Heart Fund, Dakota Aerie of the Fraternal Order of Eagles.

Keywords

  • Adrenomedullin
  • Antisense
  • Salt appetite

Fingerprint Dive into the research topics of 'Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake'. Together they form a unique fingerprint.

Cite this