Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

Charles R. Salmen; Matthew D. Hickey; Robert A. Tessler; Dan Omollo; Peter Bacchetti; Richard Magerenge; Brian Mattah; Marcus R. Salmen; Daniel Zoughbie; Kathryn J. Fiorella; Elvin Geng; Betty Njoroge; Chengshi Jin; Yong Huang; Elizabeth A. Bukusi; Craig R. Cohen; Monica Gandhi

doi:10.1097/QAI.0000000000000154

Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

Charles R. Salmen, Matthew D. Hickey, Robert A. Tessler, Dan Omollo, Peter Bacchetti, Richard Magerenge, Brian Mattah, Marcus R. Salmen, Daniel Zoughbie, Kathryn J. Fiorella, Elvin Geng, Betty Njoroge, Chengshi Jin, Yong Huang, Elizabeth A. Bukusi, Craig R. Cohen, Monica Gandhi

Family Medicine and Community Health (Twin Cities)

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.

Original language	English (US)
Pages (from-to)	311-315
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	66
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000000154
State	Published - Jul 1 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 by Lippincott Williams & Wilkins.

Keywords

Adherence
Feasibility and acceptability
Hair concentrations
Nevirapine
Pharmacologic measure
Resourcelimited setting

Publisher link

10.1097/QAI.0000000000000154

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Salmen, C. R., Hickey, M. D., Tessler, R. A., Omollo, D., Bacchetti, P., Magerenge, R., Mattah, B., Salmen, M. R., Zoughbie, D., Fiorella, K. J., Geng, E., Njoroge, B., Jin, C., Huang, Y., Bukusi, E. A., Cohen, C. R., & Gandhi, M. (2014). Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya. Journal of Acquired Immune Deficiency Syndromes, 66(3), 311-315. https://doi.org/10.1097/QAI.0000000000000154

Salmen, CR, Hickey, MD, Tessler, RA, Omollo, D, Bacchetti, P, Magerenge, R, Mattah, B, Salmen, MR, Zoughbie, D, Fiorella, KJ, Geng, E, Njoroge, B, Jin, C, Huang, Y, Bukusi, EA, Cohen, CR & Gandhi, M 2014, 'Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya', Journal of Acquired Immune Deficiency Syndromes, vol. 66, no. 3, pp. 311-315. https://doi.org/10.1097/QAI.0000000000000154

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abstract = "Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.",

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doi = "10.1097/QAI.0000000000000154",

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AU - Mattah, Brian

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AU - Zoughbie, Daniel

AU - Fiorella, Kathryn J.

AU - Geng, Elvin

AU - Njoroge, Betty

AU - Jin, Chengshi

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Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

Abstract

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